2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA Desaturase (SCD)

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Stearoyl-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a model for selective degradation of short-lived proteins of the endoplasmic reticulum (ER). SCD is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological membrane. Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively.

Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also stimulates canonical Wnt pathway and YAP activation in support of stemness and tumorigenesis. SCD facilitates metabolic reprogramming in cancer which is mediated, at least in part, by regulation of AKT, AMPK, and NF-kB via MUFAs. From the biological viewpoint, hyperexpression of SCD1 causes many metabolic disorders including obesity, insulin resistance, hypertension, and hypertriglyceridemia, etc. SCD1 is a pharmacological target in the treatment of obesity, diabetes and other metabolic diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12756
    E6446
    		Inhibitor ≥98.0%
    E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).
    E6446
  • HY-112812
    SCD1 inhibitor-1
    		Inhibitor 99.78%
    SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity.
    SCD1 inhibitor-1
  • HY-N0701
    (-)-Asarinin
    		Inhibitor 99.90%
    (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.
    (-)-Asarinin
  • HY-100249
    XEN723
    		Inhibitor 99.90%
    XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
    XEN723
  • HY-11034
    CVT-12012
    		Inhibitor 99.16%
    CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.
    CVT-12012
  • HY-113638
    CVT-11127
    		Inhibitor 99.88%
    CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.
    CVT-11127
  • HY-139077
    SCD1 inhibitor-3
    		Inhibitor 98.55%
    SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.
    SCD1 inhibitor-3
  • HY-102045
    T-3764518
    		Inhibitor 99.86%
    T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.
    T-3764518
  • HY-155403
    SCD1/5-IN-1
    		Inhibitor 99.58%
    SCD1/5-IN-1 (Compound 10) is a SCD1/5 inhibitor. SCD1/5-IN-1 can be used for research of neurological disease.
    SCD1/5-IN-1
  • HY-RS12494
    SCD Human Pre-designed siRNA Set A
    		Inhibitor

    SCD Human Pre-designed siRNA Set A contains three designed siRNAs for SCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SCD Human Pre-designed siRNA Set A
    SCD Human Pre-designed siRNA Set A
  • HY-116653
    Flurtamone
    		Inhibitor 99.97%
    Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum.
    Flurtamone
  • HY-13077
    MK-8245 Trifluoroacetate
    		Inhibitor 98.09%
    MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
    MK-8245 Trifluoroacetate
  • HY-111315
    XEN103
    		Inhibitor
    XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice.
    XEN103
  • HY-150125
    SCD1-IN-1
    		Inhibitor
    SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.
    SCD1-IN-1
  • HY-RS12495
    Scd Rat Pre-designed siRNA Set A
    		Inhibitor

    Scd Rat Pre-designed siRNA Set A contains three designed siRNAs for Scd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Scd Rat Pre-designed siRNA Set A
    Scd Rat Pre-designed siRNA Set A
  • HY-N0701R
    (-)-Asarinin (Standard)
    		Inhibitor
    (-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin (HY-N0701). This product is intended for research and analytical applications. (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.
    (-)-Asarinin (Standard)
  • HY-N0121R
    Sesamin (Standard)
    		Inhibitor
    Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.
    Sesamin (Standard)
  • HY-163472
    PR280
    		Inhibitor
    PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) (IC50=700 nM). PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide (dhCer) to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases.
    PR280
  • HY-114184
    MK-8245 analog
    		Inhibitor
    MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC50 of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects.
    MK-8245 analog
  • HY-N6807S
    Elemicin-d3
    		Inhibitor
    Elemicin-d3 is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
    Elemicin-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity